Chemistry CD (Sanctuary, B. C.)

Ther A B CD 2

ownloade short circulating half-life and side effects of IFNα affect its dosing schedule and efficacy. Fusion of IFNα mor-targeting monoclonal antibody (MAb-IFNα) can enhance potency due to increased tumor localiand improved pharmacokinetics. We report the generation and characterization of the first bispecific FNα, designated 20-C2-2b, which comprises two copies of IFNα2b and a stabilized F(ab...

Responsiveness CD 19 and CD 32 b Differentially Regulate

The nature of circulating CD 27 + CD 43 + B cells

The Rockefeller University Press J. Exp. Med. Vol. 208 No. 13 2563-2569 To the Editor: In a recent issue of The Journal of Experimental Medicine, Thomas Rothstein and colleagues, a group with long-standing expertise in the field of mouse B1 cells, reported the description of a B1 B cell subset in human blood, a population that has thus far eluded identification (Griffin et al., 2011). Mouse B1 ...

Bee sanctuary

The mysterious disappearance of entire bee colonies, known as colony collapse disorder or CCD, has mystified researchers for a couple of years now (see Curr. Biol. 17, R389). It was first observed in the US, where highly industrialised bee-keeping practices mean that colonies are shipped across the continent to work large areas of a single crop. But whether this stress or other factors are resp...

Human B Cell Responsiveness CD 19 and CD 32 b Differentially Regulate